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Electrical Submersible Pumps (ESPs) are widely used in medium to high production rate wells due to their capability to efficiently lift large volumes of fluids. However, tubing integrity failures remain a significant operational challenge in ESP wells, primarily caused by corrosion, erosion, and mechanical stress. These failures often lead to unplanned workovers, production losses, and increased operational costs. This thesis introduces a novel quantitative risk-based framework, the Tubing Integrity Risk Index (TIRI), specifically developed for ESP wells. Unlike conventional approaches that evaluate corrosion, erosion, and mechanical loading separately, TIRI integrates these three primary degradation mechanisms into a single normalized metric. The index is formulated using a Multi-Attribute Decision Analysis framework with a Weighted Sum Model, where the parameter weights are optimized using historical tubing performance data to reflect their actual contribution to failures. The methodology was applied to 82 ESP-operated wells in Field X. TIRI values were validated against tubing life performance and used to classify wells into low, medium, and high-risk categories. The validation confirmed that higher TIRI values correlate with premature tubing failures, while lower values indicate longer tubing service life. A case study comparing low-risk and high-risk wells demonstrated that TIRI can guide tubing design optimization, as high-risk wells required upgraded materials such as P - 1 1 0 with I 3Cr to sustain safe operation. The findings show that TIRI provides a systematic and data-driven method for prioritizing wells based on integrity risk. It supports risk-based decision-making for tubing material selection and preventive maintenance planning, contributing to improved tubing reliability and reduced operational costs in ESP wells ..