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Chemical injection for enhanced oil recovery (CEOR) can significantly increase oil production, but its effectiveness is highly influenced by both technical and economic factors. This study analyzes various injection scenarios using a synthetic sandstone reservoir model built with CMG STARS simulation software. The chemical components used include sodium dodecyl sulfate (SDS), TRS 10-410 combined with isobutanol (IBA), and the polymer FLOPAAM 3530S. Several parameters were varied, including slug volume, injection time and pattern, surfactant concentration, and total injected pore volume (PV). Each scenario was evaluated based on oil recovery and economic indicators such as Net Present Value (NPV), Modified Internal Rate of Return (MIRR), Payback Period (PP), and Unit Technical Cost (UTC). Results show that the combination of TRS 10-410 + IBA and polymer, with a 5-spot injection pattern, a 0.8 PV slug, 0.5 wt% concentration, and a 3-year injection duration, yielded the best performance, with an NPV of USD 14.17 million, a PP of 0.63 years, and a UTC of USD 48.87 per barrel. Sensitivity analysis identified crude oil price and operational expenditure (OPEX) as the most critical factors affecting the economic feasibility of the project. The uncertainty analysis, meanwhile, revealed that NPV and Payback Period (PP) are the most sensitive parameters to variations in input variables.