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Identification of Novel “Inks†for 3D Printing Using High-Throughput Screening: Bioresorbable Photocurable Polymers for Controlled Drug Delivery

Penulis : Iria Louzao [-]
Kontributor / Dosen Pembimbing :
  • Britta Koch, Vincenzo Taresco, Laura Ruiz-Cantu, Derek J. Irvine, Clive J. Roberts, Christopher Tuck, Cameron, Morgan R. Alexander Alexander, Richard Hague, Ricky Wildman,
Jenis Koleksi : Jurnal elektronik
Penerbit : Kimia
Fakultas : Fakultas Matematika dan Ilmu Pengetahuan Alam
Subjek : Chemistry
Kata Kunci : 3D printing, drug delivery, polymer materials, biomedical devices, sustained drug release
Sumber : www.acsami.org
Staf Input/Edit : Latifa Noor  
File : 1 file
Tanggal Input : 14 Jun 2019

A robust methodology is presented to identify novel biomaterials suitable for three-dimensional (3D) printing. Currently, the application of additive manufacturing is limited by the availability of functional inks, especially in the area of biomaterials; this is the first time when this method is used to tackle this problem, allowing hundreds of formulations to be readily assessed. Several functional properties, including the release of an antidepressive drug (paroxetine), cytotoxicity, and printability, are screened for 253 new ink formulations in a high-throughput format as well as mechanical properties. The selected candidates with the desirable properties are successfully scaled up using 3D printing into a range of object architectures. A full drug release study and degradability and tensile modulus experiments are presented on a simple architecture to validating the suitability of this methodology to identify printable inks for 3D printing devices with bespoke properties.

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