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A chemically powered jellyfish-like micromotorwas proposed by using a multimetallic shell and a DNAassembly with catalase decorations modified on the concavesurface to simulate the umbrella-shaped body and the musclefibers on the inner umbrella of jellyfish. Relying on thecatalytic generation of oxygen gas by catalase in H2O2fuel, thejellyfish-like micromotor showed good bubble-propelledmotion in different biomedia with speed exceeding 209?ms?1in 1.5% H2O2. The jellyfish-like micromotors could also beapplied for motion detection of DNA based on a displacementhybridization-triggered catalase release. The proposed jelly-fish-like micromotors showed advantages of easy fabrication, good motion ability, sensitive motion detection of DNA, and goodstability and reproducibility, indicating considerable promise for biological application.