Perpustakaan Digital ITB

Light has several advantages as the stimulus for a triggered drug release. Currently, the applications of phototriggered drug-release devices (PDDs) are largely limited by two factors: the limited tissue penetration and detrimental e ff ects caused by excitation light (ultraviolet or visible light). To address thi s disadvantage, this study developed nanocomposites based on upconversion nano- particles (UC), which could convert near-infrared light to ultraviolet ? visible light and trigger drug release. By loading UC and doxorubicin (DOX) into photoresponsive copolymer PEG-NMAB-PLA (PNP), near-infrared responsive copolymer upconversion nanocomposites (PNP-DOX-UC) were constructed. We proved that PNP-DOX-UC showed the fast release and strong cytotoxicity under near-infrared irradiation in vitro. The therapeutic e ffi cacy study indicated that PNP-DOX-UC+ hv had the enhanced antitumor e ffi ciency. In the study, UC becoming an internal ultraviolet ? visible light source for near-infrared excitation develops an applicable and e ffi cient approach to meet the requirements for UV/vis excitation, which is a major disadvantage in photosensitive materials developed for pharmaceutical and biomedical applications.