Perpustakaan Digital ITB

Acne vulgaris is a common pathogenic skin condition triggered by acne-causing bacteria. Antibiotics are commonly used as one of the treatments for acne. However, antibiotic resistance has increased, leading to the development of non-antibiotic active ingredient-based skincare products known as microbiome-friendly skincare. This study aimed to evaluate the antibacterial activity of local and imported microbiome-friendly skincare products in essence form against Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. The screening method used was agar diffusion method by determining the diameter of the inhibition zone. Minimum Inhibitory Concentration (MIC) was determined using the microdilution method, and Minimum Bactericidal Concentration (MBC) was determined using the pour plate method. The results of the antibacterial activity determination showed that product IA containing Lactobacillus ferment lysate had an MIC value of 25% against all tested acne-causing bacteria. Product IB containing Bifida ferment lysate showed antibacterial activity with an MIC value of 100% against P.acnes and S.aureus, but no activity against S.epidermidis. Product LB containing Galactomyces ferment filtrate with prebiotic extract from brown seaweed showed an MIC value of 25% against P. acnes, S. aureus, and S. epidermidis. Minimum Bactericidal Concentration (MBC) determination showed the same values as MIC, except for product IA, which had an MBC value of 50% against S. aureus. Product LA containing Galactomyces ferment filtrate had an MIC value of 100% for all tested acne-causing bacteria, with the same MBC value, except for S. aureus, which showed growth even with an MIC of 100%. Overall, all microbiome-friendly skincare products showed antibacterial activity against acne-causing bacteria.