2019 EJRNL PP HALAL EZGI GULTEKIN 1
Terbatas Open In Flip Book Yanti Sri Rahayu, S.Sos
» ITB
Terbatas Open In Flip Book Yanti Sri Rahayu, S.Sos
» ITB
Purpose Fabrication of immediate release (IR) tablet formulations with rapid release profile via fused deposition modeling
3D printing (FDM 3DP) is a challenge. The aims of this study
were to prepare IR tablets with different dissolution profiles
and to increase their in vitro dissolution rates by making physical modifications on them. Pramipexole was used as the model low-dose drug.
Methods Polymeric filaments were prepared with six different combinations of Eudragit EPO and poly(ethylene) oxide
by hot melt extrusion and 3D tablets were produced using an
FDM printer. Characterization studies for the filaments and
tablets were carried out. The printability of the filaments was
also evaluated using a novel mechanical characterization
method. Tablet formulation with optimum dissolution profile
was chosen and physical modifications (infill %, shape change
and thickness) on this formulation were made.
Results Low-dose pramipexole loading filaments and 3D tablets were homogenously prepared. The printability of the filaments was related to their flexibility. With the physical modifications, the drug release completion time of the tablets reduced to 5 min.
Conclusions The same rapid release profiles with conventional IR tablets can be reached by making only physical changes
on 3D tablets without using any filling or disintegrating
agents.