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Graphene Oxide Synergistically Enhances Antibiotic Efficacy in Vancomycin-Resistant Staphylococcus aureus

Penulis : Vimal Singh [-]
Kontributor / Dosen Pembimbing :
  • Vinod Kumar, Sunayana Kashyap, Ajay Vikram Singh, Vimal Kishore, Metin Sitti, Preeti S. Saxena, Anchal Srivastava
Jenis Koleksi : Jurnal elektronik
Penerbit : Lain-lain
Fakultas :
Subjek :
Kata Kunci : polyvalent inhibitors, graphene oxide, vancomycin, multivalent interactions 1. INTRODUCTION In the last two decades, the increasing load of communicable diseases with heavy use of antibiotics has resulted in the progression and persistence of drug-resistant infections.1 The continuous emergence of drug-resistant bacteria against the most potent antibiotics is presenting a serious threat to public health. Also, it is resulting in increased chances of serious illness, leading to death in most of the cases, with an extra expenditure of >20 billion USD annually for developing an efficient health care system.1,2 A large number of infectious bacterial strains have developed antibiotics opposition, for example, Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococci (VREs), along with those infecting to the immunocompromised conditions for, e.g., HIV/AIDS.3,4 Among others, more than 90%
Sumber : American Chemical Society
Staf Input/Edit : Irwan Sofiyan  
File : 1 file
Tanggal Input : 26 Feb 2019

2019_EJRNL_PP_Vimal_Singh_1.pdf
Terbatas Irwan Sofiyan
» ITB

The current study highlights a new polyvalent inhibitor approach based on Vancomycin conjugated with graphene oxide (Van@GO) against a Vancomycin-resistant Staphylococcus aureus (VRSA) strain. Physicochemical characteristics of the prepared Van@GO composites were studied using UV?vis and FTIR spectroscopy techniques. Characterization results confirm the attachment of Vancomycin to the graphene oxide....

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