Perpustakaan Digital ITB

Solid dispersion (SD) technique has been proven to be most successful in improvement of dissolution properties of poorly soluble drugs. This is done by using a combination of drug and polymer to enhance dissolution profile. The aim of this study is to observe the effect of fillers starch and lactose coated with PVP K30 in the improvement of the dissolution profile of poorly water soluble drug, gliclazide by spray drying method. Gliclazide is a second generation sulphonylurea used worldwide in the treatment of type 2 diabetes. It belongs to BSC Class II drug which has poor solubility but good permeability. Gliclazide binds to the ?cell sulfonylurea receptor (SUR1) which in turn blocks the potassium channel leading to depolarization of the ?cell and secretion of insulin. The solutions containing the components in different concentrations of fillers were spray dried respectively. The feed solution were evaluated for its viscosity and pH which follows the parameter of spray drying. Evaluation were conducted on the solid dispersion product such as scanning electron microscope (SEM) to obtain information regarding the morphology and the powder X-ray diffractometry (PXRD) to determine the crystal structure and polymorphism. Dissolution test was done and filler lactose of 1.0% showed better dissolution rate compared to starch. The evaluation on the SEM showed changes in morphology and the PXRD showed no polymorphism. Fillers can have affect on the dissolution and can be used as a useful tool in improving the dissolution properties of poorly water soluble drugs.