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Global climate change, driven by rising CO? emissions, poses a serious threat to Earth's sustainability, with impacts already being felt in Indonesia through more frequent natural disasters. As a major CO? emitter, Indonesia is crucial in global climate mitigation efforts. Carbon Capture and Storage (CCS) offers a solution by capturing CO? from emission sources and storing it in geological formations such as saline aquifers and depleted reservoirs. This study aims to estimate CO? storage capacity in Indonesia’s oil and gas fields, focusing on saline aquifers and depleted reservoirs. Key geological parameters—formation area, thickness, porosity, CO? density, and depth—are analyzed using the Design of Experiments (DoE) approach, specifically Response Surface Methodology (RSM) with Central Composite Design (CCD). Data from LEMIGAS, previously used for CO? storage capacity calculations, were used for recalculations and further analysis. Results show slight variations from LEMIGAS’ original estimates, likely due to different assumptions or methods. The study finds significant CO? storage potential in Indonesia, with saline aquifers having a capacity of 572.768 gigatons and depleted reservoirs holding 7.041 gigatons across 20 basins. The analysis identifies optimal storage zones based on larger formation areas, greater thickness, and deeper depths, with formation area, thickness, and depth having the greatest impact. The interactions between parameters are key to effective CCS strategies. The study also highlights uncertainties in capacity estimates and experimental design, offering recommendations for improving data resolution and model accuracy. These findings provide valuable insights for developing CCS and CCUS strategies to support Indonesia’s emission reduction goals.