Perpustakaan Digital ITB

Cardioprotective activities include all mechanisms that help to guard the heart by preventing myocardial damage. Until now, herbal medicines are being incorporated into clinical practice and become the chosen alternative treatment. Garlic (Allium sativum L.) has been traditionally used to treat cancer, diabetes, and high blood pressure and has been shown to have hepatoprotective and cardioprotective activity as well. Other garlic preparations, aged black garlic, has been developed to reduce unpleasant odor and taste of fresh raw garlic without losing its biological activities. The aim of this study was to evaluate the cardioprotective activity of fresh raw garlic and aged black garlic on male rats of Wistar strain induced by isoproterenol. The method to conduct cardioprotective effects were carried out with six test groups (1) negative control (Na-CMC 0.5%), (2) positive control (Na-CMC 0.5% and induction of isoproterenol), (3) fresh raw garlic extract at a dose of 100 mg/kg bw and induction of isoproterenol, (4) fresh raw garlic extract at a dose of 300 mg/kg bw and induction of isoproterenol, (5) aged black garlic extract at a dose of 100 mg/kg bw and induction of isoproterenol, and (6) aged black garlic extract at a dose of 300 mg/kg bw and induction of isoproterenol. The results of testing of cardioprotective effects showed that fresh raw garlic extract at a dose of 100 mg/kg bw has the highest cardioprotective effects as indicated by the percentage inhibition of overall ALT, AST, CK, CK-MB, and LDH biomarkers increases by 36.37%; 23.89%; 40.92%; 53.07%; and 31.37%, respectively.