In several recent research, BSF larva have been potential in possessing vast bioactive compounds that can provide diverse bioactivities, such as antimicrobial, antihypertensive, antioxidant with a possible beneficial impact on human health. Considering the profound benefits it offers, this study aimed to explore anti-inflammatory activities black soldier fly larvae extract and hydrolysate. The BSF Larvae extracts obtained from the extraction and fractionation process were tested for its antiinflammatory activity and was analyzed by UV spectrophotometry at detectable wavelengths obtained from various optimization and trials. The results of the anti-inflammatory activity test during the experiment showed that the BSF aqueous extract samples with concentrations of 50, 64, 128 and 256 ppm had an inhibitory effect of 39.243%, 45.154%, 61.466% and 69.504%, respectively. The IC50 obtained from the water extract is 129.326 ppm. Peptides are suspected to be present in aqueous extract samples without hydrolysis treatment through thin layer chromatography analysis. Anti-inflammatory activity is present in the aqueous extract of BSF larvae.