Perpustakaan Digital ITB

Atherosclerosis is a risk factor for cardiovascular disease which is the number one cause of death globally. Atherosclerosis is a chronic and progressive inflammatory disease characterized by the buildup of lipids and fibrous plaques in the intima lining of the arterial walls. Inflammatory pathways play a significant role in atherosclerosis that leads to acute coronary syndrome. The initial stages of atherosclerosis are often asymptomatic; when atherosclerotic plaque becomes unstable it leads to acute coronary syndrome ACS. Therefore, early detection, diagnosis, and treatment of atherosclerosis must be sought. These circumstances underpin the need of diagnostic values of inflammatory markers, warranting their routine clinical application to develop anti-atherosclerotic therapeutic approaches. The present aimed to evaluate the plasma levels of interleukin-6 (IL6), interleukin-18 (IL-18), interleukin-1?(IL-1?) and interleukin-10 (IL-10). We included 23 patients diagnosed with ACS with in duration of 48?hours of their admission in hospital and 20 healthy individuals in a case-control observational study to evaluate the plasma levels of inflammatory biomarkers and their correlation with each other and with anti-inflammatory interleukin. The mean levels of IL-6 and IL-18 were significantly higher in ACS group when compared to the control group; IL-6 = 298.65 pg/ml ± 432.93 pg/ml, p = 0.01; IL-18 = 181.45pg/ml ± 81.45pg/ml, p <0.004). A correlation analysis showed that there is a positive correlation exists between each other but there is no correlation exists between IL-1beta and IL-6, IL-18 and IL-10 with IL-18. The results indicate that IL-6 and IL-18 are associated with ACS.