Perpustakaan Digital ITB

The branch of the immune system called innate immunity has a pivotal role in host defence by recognizing general hallmarks of disease-causing agents. The intracellular protein STING, a transmembrane protein usually located on an organelle called the endoplasmic reticulum, is a key regulator of this type of immune response1. Writing in Nature, Shang et al.2 and Zhang et al.3 report full-length structures of STING, including STING in complex with the kinase protein TBK1, which initiates the downstream signalling pathway that is triggered on STING activation.