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Taking calcium supplements can reduce the risk of developing osteoporosis, but they are
not readily absorbed in the gastrointestinal tract. Nanotechnology is expected to resolve
this problem. In this study, we prepared and characterized calcium carbonate nanoparticle
to improve the solubility by using bottom-up method. The experiment was done by
titrating calcium chloride with sodium carbonate with the addition of polyvinylpyrrolidone
(PVP) as stabilizer, using ultra-turrax. Various concentrations of calcium chloride and
sodium carbonate as well as various speed of stirring were used to prepare the calcium
carbonate nanoparticles. Evaluations studied were including particle size, polydispersity
index (PI) and zeta potential with particle analyzer, surface morphology with scanning
electron microscope, and saturated solubility. In addition, to test the ability of PVP to
prevent particles growth, short stability study was performed by storing nano CaCO3
suspension at room temperature for 2 weeks. Results show that using 8000 rpm speed of
stirring, the particle size tends to be bigger with the range of 500 – 600 nm (PI between 0.2
– 0.4) whereas with stirring speed of 4000 rpm, the particle size tends to be smaller with
300 – 400 nm (PI between 0.2 – 0.4). Stirring speed of 6000 rpm produced particle size
within the range of 400 – 500 nm (PI between 0.2 – 0.4). SEM photograph shows that
particles are monodisperse confirming that particles were physically stable without any
agglomeration within 2 weeks storage. Taken together, nano CaCO3 is successfully
prepared by bottom-up method and PVP is a good stabilizer to prevent the particle growth.