ABSTRAK Vanessa Gabriela Ghozali
PUBLIC Alice Diniarti COVER Vanessa Gabriela Ghozali
PUBLIC Alice Diniarti
BAB 1 Vanessa Gabriela Ghozali
Terbatas  Alice Diniarti
» Gedung UPT Perpustakaan
Terbatas  Alice Diniarti
» Gedung UPT Perpustakaan
BAB 2 Vanessa Gabriela Ghozali
Terbatas  Alice Diniarti
» Gedung UPT Perpustakaan
Terbatas  Alice Diniarti
» Gedung UPT Perpustakaan
BAB 3 Vanessa Gabriela Ghozali
Terbatas  Alice Diniarti
» Gedung UPT Perpustakaan
Terbatas  Alice Diniarti
» Gedung UPT Perpustakaan
BAB 4 Vanessa Gabriela Ghozali
Terbatas  Alice Diniarti
» Gedung UPT Perpustakaan
Terbatas  Alice Diniarti
» Gedung UPT Perpustakaan
BAB 5 Vanessa Gabriela Ghozali
PUBLIC Alice Diniarti PUSTAKA Vanessa Gabriela Ghozali
PUBLIC Alice Diniarti
Cervical cancer is the most common cause of women’s mortality in the world. In treating
cervical cancer with radiotherapy, IAEA suggested the combination of EBRT as a primary
treatment and HDR Brachytherapy as a dosage boost. However, it is still a major problem to
treat patients within the recommended time or 8 weeks. The prolongation of the treatment
time can cause an increase of failure by 1% per day. To understand the ability of HDR
brachytherapy as a monotherapy, DOSXYZnrc was used to simulate the dose distribution of
the source inside a voxelized phantom. The dose distribution data were then used as an input
to modeled the DVH as a quality indicator and also to calculate 2 radiobiological metrics: TCP
and NTCP as a quantity measure of the treatment plan. EUD is a mathematical model used to
calculate the value of TCP and NTCP. The radiobiological parameters were evaluated for 10
fractionations of a total dose of 80 Gy. The simulation results in a high TCP value for the target
and low NTCP value for the bladder and rectum. The tumor able to achieve TCP of 99.433%
and the OARs, bladder and rectum, achieve NTCP of 0% and 0.041%, respectively. Variation of
fractionations were calculated, and it was found that rectum had a higher complication
probability than bladder when the treatment was done in 7 fractionations or more. From this
research, 6 fractionations can produce a good radiobiological result with TCP of 99.882% for
the tumor, and NTCP of 0% and 10.787% for the bladder and rectum. This configuration will
also increase the chances to finish the treatment less than 8 weeks.