Perpustakaan Digital ITB

Hypochlorous acid/hypochlorite (HOCl/ OCl?), one of the most important reactive oxygen species (ROS), plays vital roles in various physiological and pathological processes. At normal concentrations, OCl? acts as part of an immune defense system by destroying invasive bacteria and pathogens. However, nonproperly located or excessive amounts of OCl? are related to many diseases, including cancers. Thus, detection of OCl? has great importance. Owing to their high sensitivities, selectivities, fast response times, technical simplicities, and high temporal and spatial resolution, fluorescent probes are powerful tools for in vitro and in vivo sensing of target substances. This Account focuses on the development of new chemosensors for detection of OCl?, which operate by undergoing a chemical reaction with this ROS in conjunction with a change in emission properties.