2007 JRNL PP Kuo-Yuan Hwa - 1.pdf?
Terbatas  Irwan Sofiyan
» Gedung UPT Perpustakaan
Terbatas  Irwan Sofiyan
» Gedung UPT Perpustakaan
Molecular mimicry defined as similar structures
shared by molecules from dissimilar genes or by their
protein products, is a general strategy for pathogens
to infect host cells. Therefore, identification of the
molecular mimic regions of a pathogen may be helpful
to understand the disease. Severe acute respiratory
syndrome (SARS) is a new human respiratory
infectious disease caused by SARS coronavirus
(SARS-CoV). The virus uses the spike (S) protein to
interact with the angiotensin converting enzyme 2, the
host cell receptor. Our approach is to design a
workflow with multiple bioinformatics tools in
analyzing the sequence of spike protein of the SARSCoV
in searching its similarity to human proteins.
Furthermore, eleven peptides have been synthesized to
validate the in silico results.