Article Details

MOLECULAR MIMICRY BETWEEN SARS CORONAVIRUS SPIKE PROTEIN AND HUMAN PROTEIN

Oleh   Kuo-Yuan Hwa [-]
Kontributor / Dosen Pembimbing : Wan Man Lin; ROC Yung-I Hou; ROC Trai-Ming Yeh
Jenis Koleksi : Jurnal elektronik
Penerbit : Lain-lain
Fakultas :
Subjek :
Kata Kunci : Molecular mimicry defined
Sumber : Frontiers in the Convergence of Bioscience and Information Technologies 2007
Staf Input/Edit : Irwan Sofiyan  
File : 1 file
Tanggal Input : 2021-08-31 09:19:43

Generic placeholder image
2007 JRNL PP Kuo-Yuan Hwa - 1.pdf?

Terbatas
» Gedung UPT Perpustakaan


Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The virus uses the spike (S) protein to interact with the angiotensin converting enzyme 2, the host cell receptor. Our approach is to design a workflow with multiple bioinformatics tools in analyzing the sequence of spike protein of the SARSCoV in searching its similarity to human proteins. Furthermore, eleven peptides have been synthesized to validate the in silico results.