Perpustakaan Digital ITB

Mucoadhesive tablets were widely used because they release drug for long time, where the frequency of drug administered was reduced providing convenience for patients. Tablets were incorporated with polymeric binders in designing such novel drug delivery system. The aim of this study was to develop tablet formulations which had mucoadhesive properties with active ingredient of naproxen sodium using synthetic polymers such as Carbopol 940, PVP K30, and natural polymers such as sodium alginate, gelatin, and starch. The powder blend was mixed and evaluated for powder characteristics such as flowability, bulk density and tapped density. Fifteen tablet batches were formulated using direct compression method. Formulations F13, F14 and F15 undergone tablet evaluation namely hardness test, friability, weight variation, dissolution test, and swelling index determination. Dissolution test was carried out for 5 hours using USP Type 2 paddle in 900 mL of 0.1 M phosphate buffer pH 7.4 and the buffer medium was maintained at 37 ± 0.5 ºC and the speed of the paddle was set at 50 rpm. The mucoadhesive characteristic tests were carried out based on mucoadhesive time, mucoadhesive strength and force of mucoadhesion using rabbit gastrointestinal mucosal layer and a modified weighing balance method. Formulations F13, F14, and F15 showed good powder characteristic and fulfilled the tablet requirements. The formulations F13 and F15 exhibited mucoadhesive properties based on mucoadhesive time, mucoadhesive strength and force of mucoadhesion. F13 showed better mucoadhesive characteristic than F15. The mucoadhesion time of F13 was 24.03 minutes, the mucoadhesive strength was 474.71 N and the force of adhesion was 4.65 N. The use of mucoadhesive polymers with appropriate excipients produced good tablet characteristic and mucoadhesive properties.