2019_EJRL_PP_Indrajeet_J__Barve_1.pdf
Terbatas Irwan Sofiyan
» ITB
Terbatas Irwan Sofiyan
» ITB
Base-controlled regioselective synthesis of 2-
imino thiazolines and 2-thioxoimidazolin-4-ones was achieved
to use a one-pot reaction between chiral amino esters,
isothiocyanates, and ?-bromoketones/alkyl halides. This
three-component coupling reaction in acetonitrile provides
2-imino thiazolines, whereas the formation of 2-thioxoimidazolin-
4-ones was observed under basic conditions at ambient
temperature. The corresponding products were obtained in
good to excellent yield with broad substrate scope. Isolation of
thiourea and thiohydantoin intermediates disclosed the course of the reaction mechanism.