Vaccines are now known as the best intervention for ending the current ongoing COVID-19
pandemic. However, there was a delay among Malaysian citizens in the acceptance of the COVID-19
vaccine. Therefore COVID-19 vaccine hesitancy seems to be a real concern as it is still evident
despite the improvement of medical healthcare system around the world. This study is aimed to
analyse COVID-19 vaccination acceptance and post COVID-19 vaccination syndrome among
Malaysians. This study was a questionnaire based retrospective study among Malaysian citizens
whom are 15 years and above and a total of 224 respondents have participated in this survey. Result
showed that respondents indicated higher prevalence in the willingness to receive vaccination for
both first and second dose (83.5%), (86.2%). However, there were no significant differences in the
ratings of vaccination knowledge and the willingness to receive vaccination (p = 0.428), (p = 0.416).
In addition, there is a significant difference in the ratings of the side effects after receiving their first
dose and the vaccine brand that respondents have received (p=0.000). There were two types of
vaccine that was provided for the respondents which are viral vector vaccines and whole inactive
virus vaccines. Most respondents have experienced a higher percentage of experiencing side effects
after receiving viral vector vaccines (85.0-87.3 %). Fever and muscle pain have been listed has the
highest percentage of respondents whom have experienced clinical occurrence after both first
(47.3%),(45.5%) and second dose with (42.9%),(39.3%) respectively. In general, respondents in
Malaysia showed their optimism in receiving the vaccination willingly. Moreover, study shows that
viral vector vaccines cause higher prevalence of side effects among Malaysians compared to whole
inactive virus vaccines.