2017 JRNL PP Weibao Qiu - 1.pdf
Terbatas  Irwan Sofiyan
» Gedung UPT Perpustakaan
Terbatas  Irwan Sofiyan
» Gedung UPT Perpustakaan
Advances in methodologies and tools often
lead to new insights into cardiovascular diseases.
Intravascular ultrasound (IVUS) is a well-established diagnostic
method that provides high-resolution images of the
vessel wall and atherosclerotic plaques. High-frequency
(>50 MHz) ultrasound enables the spatial resolution of IVUS
to approach that of optical imaging methods. However, the
penetration depth decreases when using higher imaging
frequencies due to the greater acoustic attenuation. An
imaging method that improves the penetration depth of
high-resolution IVUS would, therefore, be of major clinical
importance. Modulated excitation imaging is known to
allow ultrasound waves to penetrate further. This paper
presents an ultrasound system specifically for modulatedexcitation-
based IVUS imaging. The system incorporates a
high-voltage waveform generator and an image processing
board that are optimized for IVUS applications. In addition,
a miniaturized ultrasound transducer has been constructed
using a Pb(Mg1/3Nb2/3)O3–PbTiO3 single crystal to improve
the ultrasound characteristics. The results show
that the proposed system was able to provide increases
of 86.7% in penetration depth and 9.6 dB in the signal-tonoise
ratio for 60 MHz IVUS. In vitro tissue samples were
also investigated to demonstrate the performance of the
system.