C. asiatica is perennial herb commonly found in tropical areas and have been widely used to treat
conditions such as leprosy, hysteria and epilepsy and is known to have diuretic, antipyretic,
antibacterial and anticancer effects. C. asiatica have also shown to treat dermatological issues such as
treating burn wounds or incisional and excisional wounds. Extract of C. asiatica have been reported to
contain triterpenoids such as asiaticoside, madecassoside, asiatic acid and madecassic acid in which
these phytochemicals have also been known to be the most medically useful. In this literature review,
research articles pertaining to the topical use of C. asiatica for wound healing as well as research articles
regarding the effect of madecassoside for wound healing were carefully reviewed. The keywords used
for searching the articles include Centella, madecassoside, wound and topical such that all of them are
used in combination together and results include articles within the publication years from 2006 to
2021 from Google Scholar, ScienceDirect, Hindawi and Semantic Scholar. This excludes literature that
focuses on non-topical, non-C. asiatica and non-wound healing topics. Meanwhile other additional
information regarding the main topic is searched accordingly to the topic and kept set between the
years 2006 to 2021, however, certain literatures outside the time range but with clearer information is
also taken into consideration. Multiple scientific studies have shown the positive effect of
madecassoside applied topically on burn wounds as well as incisional wounds, generally through the
promotion of angiogenesis as well as epithelialization during wound-healing process . However, the
majority of scientific articles detailing the effect of C. asiatica extract as well as the extracts’ made into
a topical formulation provides information that effects are also due to asiaticoside too, therefore it is
hard to determine just madecassoside’s effect. Moreover, since madecassoside is also very close In
polarity to asiaticoside, it is generally requires effort to separate them. To conclude, madecassoside is
proven to be beneficial for wound healing activity, shown by the topical applications of it just as an
extract on its own, or formulated into creams, sprays or hydrogels; however, there certainly needs to be more studies to be conducted to analyze whether the wound healing effect of madecassoside itself
is better than asiaticosides and its aglycones or not and for now, the combination of madecassoside
and other centellosides might be more reasonable to aid wound-healing.