REVIEW ON WOUND-HEALING ACTIVITIES OF MADECASSOSIDE ISOLATED FROM CENTELLA ASIATICA AS TOPICAL FORMULATIONS
C. asiatica is perennial herb commonly found in tropical areas and have been widely used to treat conditions such as leprosy, hysteria and epilepsy and is known to have diuretic, antipyretic, antibacterial and anticancer effects. C. asiatica have also shown to treat dermatological issues such as treating burn wounds or incisional and excisional wounds. Extract of C. asiatica have been reported to contain triterpenoids such as asiaticoside, madecassoside, asiatic acid and madecassic acid in which these phytochemicals have also been known to be the most medically useful. In this literature review, research articles pertaining to the topical use of C. asiatica for wound healing as well as research articles regarding the effect of madecassoside for wound healing were carefully reviewed. The keywords used for searching the articles include Centella, madecassoside, wound and topical such that all of them are used in combination together and results include articles within the publication years from 2006 to 2021 from Google Scholar, ScienceDirect, Hindawi and Semantic Scholar. This excludes literature that focuses on non-topical, non-C. asiatica and non-wound healing topics. Meanwhile other additional information regarding the main topic is searched accordingly to the topic and kept set between the years 2006 to 2021, however, certain literatures outside the time range but with clearer information is also taken into consideration. Multiple scientific studies have shown the positive effect of madecassoside applied topically on burn wounds as well as incisional wounds, generally through the promotion of angiogenesis as well as epithelialization during wound-healing process . However, the majority of scientific articles detailing the effect of C. asiatica extract as well as the extracts’ made into a topical formulation provides information that effects are also due to asiaticoside too, therefore it is hard to determine just madecassoside’s effect. Moreover, since madecassoside is also very close In polarity to asiaticoside, it is generally requires effort to separate them. To conclude, madecassoside is proven to be beneficial for wound healing activity, shown by the topical applications of it just as an extract on its own, or formulated into creams, sprays or hydrogels; however, there certainly needs to be more studies to be conducted to analyze whether the wound healing effect of madecassoside itself is better than asiaticosides and its aglycones or not and for now, the combination of madecassoside and other centellosides might be more reasonable to aid wound-healing.