Perpustakaan Digital ITB

Alpinia galanga Linn. (greater galangal), Curcuma longa Linn. (turmeric) and Zingiber officinale var. Rubrum (red ginger) are plants from Zingiberaceae family. They are known for many healing properties such as antiulcerative, antidiuretic and anthelmintic. Ascaris lumbricoides causes ascariasis which is the most common helminthic infection. A. lumbricoides is indistinguishable with A. suum. This study aims to determine the in vitro anthelmintic activity of ethanolic extract rhizome A. galanga, C. longa and Z. officinale var. Rubrum on A. suum. Anthelmintic activity was evaluated by measuring the time taken for the helminths to paralyze. Paralysis is determined by placing an unmoving helminth in warm water and observing its movement. Data obtained was analysed using one-way anova. The results obtained for time of paralysis were A. galanga 3.90 and 2.58 hours; C. longa 8.33 and 3.15 hours and Z. officinale var. Rubrum 7.08 and 5.08 hours for 10 and 70 mg/mL respectively. All test groups underwent flaccid paralysis and showed a significant difference (p<0.05) when compared with negative control normal saline with time of death 72 hours. The group treated with A. galanga and C. longa 70mg/mL showed no significant difference (p>0.05) when compared to pyrantel pamoate 0.1mg/mL with time of paralysis 3.13 hours. In conclusion, A. galanga and C. longa have potential to be developed as alternative anthelmintic drug.