2020 EJRNL PP Lei Ma -1.pdf
Terbatas Irwan Sofiyan
» ITB
Terbatas Irwan Sofiyan
» ITB
Polytetrafluoroethylene (PTFE) is one of the polymers
extensively applied in biomedicine. However, the application of PTFE
as a small-diameter vascular graft results in thrombosis and intimal
hyperplasia because of the immune response. Therefore, improving
the biocompatibility and anticoagulant properties of PTFE is a key to
solving this problem. In this study, a hydroxyl group-rich surface was
obtained by oxidizing a benzoin-reduced PTFE membrane. Then,
chondroitin sulfate (CS), an anticoagulant, was grafted on the surface
of the hydroxylated PTFE membrane using 3-aminopropyltriethoxysilane.
The successful modification of the membrane in each step was
demonstrated by Fourier transform infrared spectroscopy and X-ray
photoelectron spectroscopy. Hydroxylation and the grafting of CS
greatly increased the hydrophilicity and roughness of membrane
samples. Moreover, the hydroxylated PTFE membrane enhanced the adhesion ability of endothelial cells, and the grafting of CS also promoted the proliferation of endothelial cells and decreased platelet adhesion. The results indicate that the PTFE membranes grafted with CS are able to facilitate rapid endothelialization and inhibit thrombus formation, which makes the proposed method outstanding for artificial blood vessel applications.