2020 EJRNL PP Ryan J. Lake -1.pdf
Terbatas Irwan Sofiyan
» ITB
Terbatas Irwan Sofiyan
» ITB
Metal ions can be beneficial or toxic depending on their identity,
oxidation state, and concentration. Therefore, the ability to detect and quantify different
types of metal ions using portable sensors or in situ imaging agents is important for better
environmental monitoring, in vitro medical diagnostics, and imaging of biological systems.
While numerous metal ions in different oxidation states are present in the environment
and biological systems, only a limited number of them can be detected effectively using
current methods. In this Account, we summarize research results from our group that
overcome this limitation by the development of a novel class of activity-based sensors
based on metal-dependent DNAzymes, which are DNA molecules with enzymatic activity......