2020 EJRNL PP Xavier Kesse -1.pdf
Terbatas Irwan Sofiyan
» ITB
Terbatas Irwan Sofiyan
» ITB
Sol?gel-derived bioactive glass nanoparticles (BGNs)
are fascinating materials for bone regeneration. In the literature, it can
be found that their specific surface area and their calcium content
(Ca/Si ratio) are the two key parameters impacting strongly the
particles’ bioactivity. Nevertheless, in most studies, in vitro bioactivity
tests are performed on a series of materials where both the
composition and the specific surface area are varied. It is thus
difficult to unravel the effect of each parameter independently. In this
study, spherical and monodispersed BGNs with different Ca/Si ratios
and a similar specific surface area have been synthesized by a
modified Sto?ber method in order to specify the impact of the calcium
content only. The mineralization studies performed in simulated
body fluid showed that the bioactivity increases with the amount of calcium incorporated in the glass matrix. However, this effect is not significant in the composition interval studied (7?15% mol of CaO). Such a result proves that the effective Ca/Si ratio is not the major parameter that affects the bioactivity of sol?gel binary BGs. In vitro biocompatibility assessment during 3 and 7 days using human mesenchymal stem cells in contact with the sample showing the fastest mineralization proved its noncytotoxicity. Hence, biomedical applications can be intended for this sample.