2020 EJRNL PP Da Xie -1.pdf
Terbatas Irwan Sofiyan
» ITB
Terbatas Irwan Sofiyan
» ITB
Fluorine magnetic resonance imaging (19F
MRI) is a promising bioimaging technique due to the
favorable magnetic resonance properties of the 19F nucleus
and the lack of detectable biological background signal. A
range of imaging agents have been developed for this imaging
modality including small molecule perfluorocarbons, fluorinerich
macromolecules and nanoparticles, and paramagnetic
metal-containing agents. Incorporation of paramagnetic metals
into fluorinated agents provides a unique opportunity to
manipulate relaxation and chemical shift properties of 19F
nuclei. Paramagnetic centers will enhance relaxation rates of
nearby 19F nuclei through paramagnetic relaxation enhancement
(PRE). Further, metals with anisotropic unpaired electrons can induce changes in 19F chemical shift through pseudocontact shift (PCS) effects. PRE and PCS are dependent on the nature of the metal center itself, the molecular scaffold surrounding it, and the position of the 19F nucleus relative to the metal center.