2015 EJRNL PP S. Misagh Imani 1.pdf)u
Terbatas Irwan Sofiyan
» ITB
Terbatas Irwan Sofiyan
» ITB
Stent versus stent’ studies are a kind of randomized trials which are designed to
show the superiority of the new stent designs compared with the previously approved ones. These
studies are usually used by regulatory agencies, such as the U.S. Food and Drug Administration
(FDA), to give an approval to new stent designs. The problem with these clinical trials is their
high cost and difficulty. In this paper, a numerical alternative for ‘stent versus stent’ complicated
clinical studies is presented.A finite element model is developed to investigate the influence of stent
design on the outcome after coronary stent placement. Two commercially available stents (the
NIR and Multi-Link stents) are modeled and their behavior during the deployment is compared
in terms of stress distribution, radial gain, outer diameter changes and foreshortening. Moreover,
the effect of stent design on the restenosis rate is investigated by comparing the stress distribution
within the arteries. An analysis of the arterial wall stresses in the stented arteries indicates that
theMulti-Link stent design causes lower stress to an atherosclerotic vessel with a localized stenotic
lesion compared to the slotted tube NIR design. The findings correlate with the observed clinical
restenosis rates, which have reported higher restenosis rates in the NIR compared with the Multi-
Link stent design.