2015 EJRNL PP Haosen Wang 1.pdf)u
Terbatas Irwan Sofiyan
» ITB
Terbatas Irwan Sofiyan
» ITB
Cell adhesion plays an important role in cell physiology. A better understanding
of this process could facilitate many clinical therapies. In this study, Rat bone marrow-derived
mesenchymal stem cells (rBMSCs) were cultured on glass substrate, and the morphology and
adhesion strength were characterized. The cell morphology was defined as spherical, adhesive,
and spreading. The adhesion strengths of the different morphologies exhibited different distribu-
tion patterns. The spherical cells exhibited low adhesion strength; the adhesive cells exhibited
rapidly increasing adhesion strength while their diameters remained relatively constant. The ad-
hesion strength increased with the cell diameter in the spreading cells. These findings suggest
that adhesion strength can be quickly assessed by examining the cell morphology.