2019_EJRNL_PP_Wan-you_He-1.pdf
Terbatas Irwan Sofiyan
» ITB
Terbatas Irwan Sofiyan
» ITB
Painful diabetic neuropathy (PDN) is among the common
complications in diabetes mellitus (DM), with its underlying mechanisms
largely unknown. Synapsin II is primarily expressed in the spinal dorsal horn,
and its upregulation mediates a superfluous release of glutamate and a
deficiency of GABAergic interneuron synaptic transmission, which is directly
implicated in the facilitation of pain signals in the hyperalgesic nociceptive
response. Recently, synapsin II has been revealed to be associated with the
modulation of neurite outgrowth, whereas the process of this neuronal
structural neuroplasticity following neuronal hyperexcitability still remains
unclear. In this study, we found that under conditions of elevated glucose,
TNF-? induced the activation of mTOR, mediating the upregulation of
synapsin II and neurite outgrowth in dorsal horn neurons....