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This work describes for thefirst time the fabrication and characterization of multicomponent interpenetratingnetworks composed of collagen I, hyaluronic acid, and poly(ethylene glycol) diacrylate for the 3D culture of human neural stemcells, astrocytes, and microglia. The chemical composition of the scaffolds can be modulated while maintaining values ofcomplex moduli within the range of the mechanical performance of brain tissue (?6.9 kPa) and having cell viability exceeding84%. The developed scaffolds are a promising new family of biomaterials that can potentially serve as 3Din vitromodels forstudying the physiology and physiopathology of the central nervous system.