2019_EJRNL_PP_S__SANTANA-VIERA_1.pdf
Terbatas Lili Sawaludin Mulyadi
» ITB
Terbatas Lili Sawaludin Mulyadi
» ITB
Cytostatic drugs are compounds used to fight cancer, which may be excreted after
administration to patients, and eventually reach wastewater. Given the high incidence of
cancer and the properties of drugs, the drug concentrations in water systems should be
evaluated.
We present the optimization, development and application of a solid phase
extraction (SPE) method for the determination of eight cytostatic compounds of
different classes in wastewater and seawater samples. We compared four SPE cartridges
prior to their determination by Ultra-High Performance Liquid Chromatography tandem
Mass Spectrometry. For wastewater samples, the Oasis HLB cartridge gave the best
recoveries, which were higher than 65% in most cases, achieving limit of detections
(LODs) of 1.68–103.95 ng·L-1
. In seawater samples, the Bond Elut cartridge afforded
the best recoveries greater than 70%, with LODs of 0.95–5.14 ng·L-1
.The optimal procedure was applied in four hospital wastewater effluent samples
taken during one year, and in different influents and effluents from wastewater
treatment plants and seawater from marine outfalls taken in eight campaigns during two
years, in Gran Canaria island (Spain). Results showed that etoposide was present in
influents of wastewater treatment plants in several months and different wastewater
treatment plants and hospital effluents in the range 375.8 – 5141 ng·L-1
, while
cyclophosphamide was present in some months in effluents from only one wastewater
treatment plant and hospital effluents in the range 55.94 – 1212 ng·L-1
. Vinblastine and
vincristine were detected in one sample of hospital at concentrations of 1836 ng·L-1
and
1851 ng·L-1
, respectively.