2017_EJRNL_PP_Olga_Sokolowska_1.pdf
Terbatas Irwan Sofiyan
» ITB
Terbatas Irwan Sofiyan
» ITB
Stimulator of interferon genes (STING) is an
adaptor protein that plays an important role in the activation
of type I interferons in response to cytosolic nucleic
acid ligands. Recent evidence indicates involvement of the
STING pathway in the induction of antitumor immune
response. Therefore, STING agonists are now being
extensively developed as a new class of cancer therapeutics.
However, little is known about the consequences of
activated STING-mediated signaling in cancer cells on the
efficacy of the antitumor treatment. It has been shown that
activation of the STING-dependent pathway in cancer cells
can result in tumor infiltration with immune cells and
modulation of the anticancer immune response. Understanding
the function of STING pathway in cancer cells
might provide important insights into the development of
effective therapeutic strategies. This review focuses on the
role of STING pathway in cancer cells, the largely
unknown topic that has recently emerged to be important in
the context of STING-mediated antitumor responses.