Perpustakaan Digital ITB
The branch of the immune system called
innate immunity has a pivotal role in
host defence by recognizing general
hallmarks of disease-causing agents. The
intracellular protein STING, a transmembrane
protein usually located on an organelle called
the endoplasmic reticulum, is a key regulator
of this type of immune response1. Writing in
Nature, Shang et al.2 and Zhang et al.3 report
full-length structures of STING, including
STING in complex with the kinase protein
TBK1, which initiates the downstream signalling
pathway that is triggered on STING
activation.