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PENGEMBANGAN FORMULA SISTEM DISPERSI PADAT TABLET IBUPROFEN-PVP K-34

Master Theses from #PUBLISHER# / 2006-03-20 14:38:38
Oleh : Timbul Partogi H. Simorangkir, S2 - Pharmacy
Dibuat : 2002-00-00, dengan 1 file

Keyword :

Dispersion formulation systems, Cromatography, X-ray diffraction
Subjek :
Practical pharmacy - Tablets

Kepala Subjek :
Pharmacology

Nomor Panggil (DDC) : T 615.43 SIM
Sumber pengambilan dokumen : 20051199

Abstrak


Telah dibuat sistem dispersi padat Ibuprofen - PVP K-30 secara pelarutan dan dikarakterisasi secara: kromatograt lapis tipis , spektroskopi inframerah, differential scanning calorimetry, difraksi sinar X dan uji disolusi. Hasil menunjukkan tidak terjadi interaksi kimia pads sistem tersebut. Kecepatan disolusi sistem dispersi padat meningkat dengan adanya reduksi ukuran partikel dan transformasi bentuk kristal. Dispersi padat diformulasi dalam bentuk tablet dan dibandingkan dengan tablet yang ada di perdagangan. Keduanya menunjukkan hasil uji disolusi yang memenuhi syarat Farmakope Indonesia edisi keempat.

Deskripsi Alternatif :

Abstrack

Solid dispersions of Ibuprofen - PVP K-30 prepared by solvent method, and its characterization by thin layer chromatography , infrared absorption spectroscopy, differential scanning calorimetry, X-ray diffraction analysis and dissolution test had been studied. Result showed that there was no chemical interaction was found beetwen the ingridients. The dissolution rate of system increased by its particle size reduction and transformation of its crystallin forms.The solid dispersion system was formulated into tablet dosage form and compared to that of commercial tablet. Result showed that both tablets fulfilled the dissolution test requirement of the 4th edition Indonesian Pharmacopoeia.

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Kontributor...

  • Pembimbing 1
    Goeswin Agoes, Prof.Dr.

    Pembimbing 2
    Tri Suciati, Dra., M.Si.

    Scan :
    Hidayat (2006-03-17)

    , Editor: hidayat@#publisher#

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