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KORELASI ANTARA UKURAN GRANUL ASETAMINOFEN

2007
Undergraduate Theses from JBPTITBPP / 2012-05-31 11:37:00
Oleh : NIZAR ABDUSSALAM, School of Life Sciences and Technology
Dibuat : 2007-11-16, dengan 8 file

Keyword : granulation,fluidized bed dryer
Subjek : Sains dan Teknologi
Sumber pengambilan dokumen : 2007 TA PP NIZAR ABDUSSALAM

ABSTRAK




Dalam proses granulasi, pembentukan granul dengan distribusi ukuran tertentu memegang peranan yang sangat penting. Pengisian masa cetak ke dalam ruang pencetakan berlangsung secara volumetrik. Adanya perbedaan distribusi ukuran granul diperkirakan dapat mempengaruhi jumlah masa cetak yang mengisi ruang cetak. Granul dengan distribusi ukuran yang berbeda-beda dihasilkan dari alat fluidized bed dryer yang kemudian masing-masing dicetak dengan menggunakan punch berdiameter 7, 10, dan 12 mm. Karakteristik tablet yang dihasilkan dievaluasi meliputi keragaman bobot, kekerasan, keragaman ukuran, friksibilitas, friabilitas, uji waktu hancur, dan penetapan kadar asetaminofen dalam tablet. Terdapat korelasi antara perbedaan ukuran granul dengan variasi bobot tablet yang dihasilkan. Granul yang didominasi ukuran besar (kasar) menghasilkan penyimpangan bobot yang tinggi dibandingkan granul yang didominasi ukuran kecil (halus) jika dicetak pada ukuran diameter punch 7, 10, dan 12 mm.

Deskripsi Alternatif :

ABSTRACT




In granulation process, granule formation with certain size distribution is very important. Granule filling process into the dies is volumetric. The difference of granule size distribution is predicted to influence the amount of tablet mass flowing into the dies. Granules with various size distribution were prepared using fluidized bed dryer and tableted by three different diameter of punches 7, 10, and 12 mm respectively. The characteristic of produced tablets that was evaluated included size variation, weight and content uniformity, hardness, disintegration time, friability, and friction ability. There is correlation between various size of granules with produced tablet weight. Granules which are dominant by coarse size will produce higher weight deviation than those of fine if were tableted by 7, 10, and 12 mm diameter of punch.

Copyrights : Copyright (c) 2007 by ITB Central Library. Verbatim copying and distribution of this entire article is permitted by author in any medium, provided this notice is preserved.

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  • Sundani Nurono Soewandhi Dr. rer. nat., Editor: delviana fransiska

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