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FORMULASI MIKROEMULSI DL-ALFA TOKOFEROL ASETAT DENGAN BASIS MINYAK KELAPA MURNI DAN UJI AKTIVITAS ANTIOKSIDAN

Undergraduate Theses from JBPTITBPP / 2012-06-19 14:23:57
Oleh : Lisa Ayu Larasati (NIM 107 03 075), S1 - Department of Pharmacy
Dibuat : 2007-09-00, dengan 8 file

Keyword : Microemulsions, dl-alpha tocopherol acetate, virgin coconut oil, antioxidant,
Kepala Subjek : Medical Sciences

Abstrak :



Formulasi mikroemulsi dengan kombinasi minyak kelapa murni dan dl-alfa tokoferol asetat bertujuan untuk meningkatkan aktivitas antioksidan sediaan telah dilakukan. Pengembangan sediaan mikroemulsi dibuat dengan dl-alfa tokoferol asetat, minyak kelapa murni, emulgator Cremophor ELP, dan kosurfaktan etanol 95%. Stabilitas sediaan mikroemulsi dievaluasi dengan metode freeze thaw, serta pengukuran pH dan viskositas sediaan yang dilakukan selama penyimpanan 8 minggu. Aktivitas antioksidan mikroemulsi diuji secara in vitro dengan metode peredaman radikal bebas 2,2-difenil-1-pikrilhidrazil (DPPH). Aktivitas antioksidan dapat dilihat dari pengurangan jumlah DPPH yang ditandai dengan penurunan serapan DPPH pada spektrofotometer. Formulasi mikroemulsi yang terbaik adalah mikroemulsi dengan kandungan minyak kelapa murni 6%, dl-alfa tokoferol asetat 1%, Cremophor ELP 36%, serta perbandingan Cremophor ELP dan etanol (3 : 1). Peredaman DPPH konsentrasi dl-alfa tokoferol asetat 1000 bpj pada mikroemulsi kombinasi dl-alfa tokoferol asetat dan minyak kelapa murni adalah 13,71+/-0,42 %; mikroemulsi alfa tokoferol asetat sebesar 5,23+/-0,39 %, sedangkan larutan dl-alfa tokoferol asetat sebesar 9,64+/-0,77 %. Formula mikroemulsi dengan kombinasi minyak kelapa murni dan dl-alfa tokoferol asetat memiliki aktivitas antioksidan yang lebih tinggi dibandingkan dengan mikroemulsi dl-alfa tokoferol asetat tanpa minyak kelapa murni.

Deskripsi Alternatif :

Abstract :



Formulation of microemulsions with combination of virgin coconut oil and dl-alpha tocopherol acetate to improve its antioxidant activity had been done. Microemulsion was prepared using dl-alpha tocopherol acetate, virgin coconut oil, Cremophor ELP as emulgator, and ethanol 95% as cosurfactant. The stability of the microemulsion was evaluated by freeze thaw, pH, and viscosity of the preparations were measured during the storage for eight weeks. The antioxidant activity microemulsion was evaluated following in vitro evaluation using the inhibition of free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). The Antioxidant activities was determinated by decreasing absorbancy of DPPH with spectrophotometer. The best formula of microemulsion was composed of virgin coconut oil 6%, dl-alpha tocopherol acetate 1%, Cremophor ELP 36%, with a ratio of Cremophor ELP and ethanol (3:1). Inhibition of DPPH with concentration of dl-alpha tocopherol acetate at 1000 ppm in microemulsion combination of dl-alpha tocopherol acetate and virgin coconut oil was 13.71+/-0.42 %; microemulsion of dl-alpha tocopherol acetate was 5.23+/-0.39 %; solution of dl-alpha tocopherol acetate was 9.64+/-0.77 %. The microemulsion of dl-alpha tocopherol acetate in combination with virgin coconut oil had higher activities than without virgin coconut oil.

Copyrights : Copyright (c) 2007 School of Pharmacy ITB.



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