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ANESTESI LOKAL DENGAN LIDOKAIN - ADRENALIN MELALUI IONTOFORESIS PADA KELINCI
Oleh : Lestiani H. Sutrisno, S2 - Pharmacy
Dibuat : 1988-00-00, dengan 10 file
Keyword : Local anaesthetic effect, Lidocaine-epinephrine, Iontophoresis
Kepala Subjek : Medical Sciences
Nomor Panggil (DDC) : T 615.781 SUT
Abstrak:
Telah dilakukan percobaan terhadap efek anestetika lokal lodokain-adrenalin melalui iontoforesis pada kelinci.
Evaluasi efek anestesia lokal dilakukan menggunakan uji tusukan dan uji arus listrik intermiten. Antara kedua cara evaluasi ini ternyata didapatkan adanya hubungan yang erat (koefisien korelasi masing-masing perlakuan antara 0,84-0,99).
Perbandingan antara dua produk (buatan pabrik dan buatan sendiri) dengan konsentrasi lidokain sama, dan jenis adrenalin yang berbeda didapatkan perbedaan basil anestesia lokal yang cukup bermakna (P<0,05), yaitu buatan sendiri memberikan efek yang lebih besar.
Efek anestesia lokal dengan cara suntikan subkutan menghasilkan anestesia yang jauh lebih besar (lebih dari tiga jam) dibandingkan dengan cara iontoforesis (kurang dari satu jam).
Hasil efek anestesia lokal yang terbesar dari berbagai sediaan lidokain-adrenalin dalam percobaan ini adalah lidokain HC1 2% dengan kandungan adrenalin bitartrat 1:80.000.
Abstract:
The local anaesthetic effect of lidocaine-epinephrine preparations administered by iontophoresis has been studied on rabbits.
The evaluation of the anaesthetic effect was done by the prick test and by intermittent electric current test. A strong relation between the two methods was found (the corelation factor of each treatment is between 0,84-0,99).
A comparison between two products (factory made and the other one prepared in the laboratory) with the same concentration of lidocaine and different salts of epinephrine resulted in a meaningful difference of anesthesia (P<0,05), the one prepared in the laboratory having the greater effect.
The effect of local anaesthesia produce by subcutan injection was much greater (more than three hours) compare to the one produce by iontophoresis (less than one hour).
Among the various lidocaine-epinephrine preparations studied in this experiment for their local anaesthetic effect, the greatest effect was observed with the preparation containing lidocaine HCl 2% and epinephrine bitartrat 1:80.000.
Copyrights : Copyright (c) 1988 by School of Pharmacy ITB. Information Dissemination Right @2008 ITB Central Library, Jl. Ganesha 10 Bandung,40132, Indonesia. Verbatim copying and distribution of this entire article is permitted by author to ITB Central Library in any medium, provided this notice is preserved.
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| Properti | Nilai Properti |
|---|---|
| ID Publisher | JBPTITBPP |
| Organisasi | S2 - Pharmacy |
| Nama Kontak | Drs. Mahmudin, SIP. |
| Alamat | Jl. Ganesha 10 |
| Kota | Bandung |
| Daerah | Jawa Barat |
| Negara | Indonesia |
| Telepon | 62-22-2509118, 2500089 |
| Fax | 62-22-2500089 |
| E-mail Administrator | digilib@lib.itb.ac.id |
| E-mail CKO | digilib@lib.itb.ac.id |
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- Pembimbing: J.R. Wattimena, Dr., M.Sc.
Scanner : Novian Kurniawan
, Editor: Novian Kurniawan
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