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PENGARUH MILLING TERHADAP LAJU DISOLUSI CAMPURAN METAMPIRON FENILBUTASON (7:3)
Oleh : ARIS HARYANA (NIM: 10702058), S1 - Department of Pharmacy
Dibuat : 2007-07-00, dengan 8 file
Keyword : milling, metampiron fenilbutason
Subjek : Science and Pharmacy Technology
Kepala Subjek : Medical Sciences
ABSTRAK:
Dalam proses farmasetika, milling merupakan proses yang umum dilakukan untuk menghasilkan ukuran partikel yang diharapkan. Selama proses milling dapat muncul fenomena interaksi fisika antar bahan baku. Salah satu dampak terjadinya interaksi fisika adalah terjadinya perubahan laju disolusi. Untuk mengetahui adanya interaksi fisika antara metampiron dan fenilbutason selama milling, perlu dilakukan analisis difraktogram sinar X, termogram DSC, serta diamati perubahan laju disolusi metampiron dan fenilbutason. Data difraktogram difraksi sinar X dan termogram DSC menunjukkan terjadinya interaksi fisika campuran metampiron dan fenilbutason (7:3) hasil milling 5,5 jam dan 18 jam yang menyebabkan peningkatan laju disolusi fenilbutason. Laju disolusi metampiron pada campuran hasil milling 5,5 jam tidak berubah. Penurunan laju disolusi metampiron terjadi setelah milling 18 jam.
ABSTRACT:
In pharmaceutical process, milling is a common process to produce particle in certain expectation size. Impact of milling process could lead to physical interaction. Dissolution rate will change as an impact of physical interaction. To observe physical interaction between methampyrone and phenylbutazone during milling process, is needed to analyze its X ray diffractogram, DSC thermogram and dissolution rate. Data of X ray diffractogram, differential scanning calorimetry and dissolution test, showed that physical interaction was occurred after 5,5 hours and 18 hours of milling and cause enhancement of dissolution rate of phenylbutazone. Dissolution rate of methampyrone was constant after 5,5 hours of milling. Decreasing dissolution rate of methampyrone was occured after 18 hours of milling.
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| Properti | Nilai Properti |
|---|---|
| ID Publisher | JBPTITBPP |
| Organisasi | S1 - Department of Pharmacy |
| Nama Kontak | Drs. Mahmudin, SIP. |
| Alamat | Jl. Ganesha 10 |
| Kota | Bandung |
| Daerah | Jawa Barat |
| Negara | Indonesia |
| Telepon | 62-22-2509118, 2500089 |
| Fax | 62-22-2500089 |
| E-mail Administrator | digilib@lib.itb.ac.id |
| E-mail CKO | digilib@lib.itb.ac.id |
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- Pembimbing: Sundani Nurono Soewandhi, Dr. rer. nat.
Scanner: Arnaz Driyastika M
(2007-11-21), Editor: driyastika
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